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Introduction to 3,4-CTMP Powder;

3,4-CTMP (3,4-Dichloromethylphenidate), also known as 3,4-DCMP, is a potent synthetic stimulant belonging to the phenidate class of compounds. It is a structural analogue of methylphenidate, distinguished by the addition of chlorine atoms at the 3 and 4 positions of the phenyl ring . This seemingly minor chemical modification dramatically alters the compound’s pharmacological profile, resulting in significantly enhanced potency and a longer duration of action .

Originally developed and tested in the 1990s as a potential therapeutic agent, 3,4-CTMP has since emerged as a research chemical of significant interest in neuropharmacological studies . As a certified reference material, it is primarily utilized in forensic and analytical applications, including method development, quality control, and transporter binding assays . At 4mmcchems, we supply premium-grade 3,4-CTMP Powder to researchers and professionals worldwide, with a focus on fast, discreet shipping across Europe.

Product Specifications

Product Name: 3,4-CTMP Powder (3,4-Dichloromethylphenidate)

Synonyms: 3,4-DCMP, threo-3,4-Dichloromethylphenidate

CAS Number: 214149-42-5

Molecular Formula: C₁₄H₁₇Cl₂NO₂

Molecular Weight: 302.20 g/mol

Purity: ≥ 98% (verified by third-party HPLC/GC-MS testing)

Form: Crystalline powder

Storage: -20°C for long-term stability

Availability: In stock, ready for immediate dispatch

Chemical Properties and Mechanism of Action

3,4-CTMP acts as a potent inhibitor of the dopamine transporter (DAT) and norepinephrine transporter (NET), with negligible activity at the serotonin transporter (SERT) . By blocking these transporters, it increases the extracellular concentrations of dopamine and norepinephrine in the synaptic cleft, leading to enhanced catecholaminergic signaling .

Key Pharmacological Data

Research has established the potent activity of 3,4-CTMP at monoamine transporters, demonstrating its significantly enhanced potency compared to methylphenidate:

• DAT Binding Affinity (Ki): 1.4 nM for 3,4-CTMP versus 110 nM for methylphenidate, representing an approximately 78-fold increase in binding affinity

• DAT Uptake Inhibition (IC₅₀): 15 nM, demonstrating potent dopamine reuptake inhibition

• NET Inhibition: More than 10-fold more potent than methylphenidate at inhibiting norepinephrine uptake

• Functional Dopamine Efflux: In rat nucleus accumbens brain slices, 3,4-CTMP at 0.1-1 μM increased evoked dopamine efflux by approximately 6-fold, compared to only 4-fold for methylphenidate at a 10-fold higher concentration (10 μM)

Mechanism Distinction

Importantly, studies confirm that 3,4-CTMP does not increase basal (unstimulated) levels of dopamine or norepinephrine, reinforcing its classification as a pure reuptake inhibitor rather than a releasing agent . This mechanism is characterized as “cocaine-like” rather than “amphetamine-like” in research models .

Why Choose 4mmcchems?

1. Uncompromising Quality

We source our 3,4-CTMP Powder from certified manufacturers with strict adherence to Good Manufacturing Practice (GMP) guidelines. Every batch undergoes independent HPLC and GC-MS testing to guarantee purity and potency, meeting the ≥98% purity threshold required for analytical reference materials.

2. Discreet and Secure Packaging

Your privacy is paramount. All orders are shipped in plain, unbranded packaging with no external markings indicating contents. Tamper-evident seals ensure security throughout transit.

3. Worldwide Shipping with European Focus

4mmcchems operates a robust global logistics network. We offer fast, reliable shipping to customers worldwide, with a particular emphasis on European markets:

• European Shipping: 3,4-CTMP has been detected in amnesty bin samples in the UK and is subject to monitoring across Europe . We have optimized shipping routes to ensure timely delivery to all EU member states, the UK, Switzerland, and more.

• Fast Transit Times: Typical delivery to European destinations ranges from 3 to 7 business days.

• Tracking Provided: Every order comes with a tracking number for real-time shipment monitoring.

4. Competitive Pricing and Bulk Discounts

We offer tiered pricing for bulk orders, making 4mmcchems the cost-effective choice for large-scale research projects. Contact our sales team for custom quotes.

5. Responsive Customer Support

Our knowledgeable team is available to answer queries regarding product specifications, shipping, and order status. We prioritize clear and prompt communication.

Safety and Regulatory Information

3,4-CTMP is a regulated substance in many jurisdictions. As a potent phenidate analogue, it is subject to monitoring and control under various national and international frameworks.

Important Considerations for Researchers:

• Controlled Status: 3,4-CTMP is subject to regulation in many countries. It is the customer’s responsibility to verify the legal status of this product in their jurisdiction before placing an order.

• Research Use Only: This product is intended for research, forensic, and analytical applications only. Not for human or veterinary use .

• Handling Precautions: Standard laboratory safety protocols should be followed when handling this compound. Due to its high potency, appropriate personal protective equipment (PPE) is recommended.

Documented Research Concerns

Research literature notes that 3,4-CTMP displays agonist activity at the 5-HT2B receptor, which is a cause for concern as acute 5-HT2B agonism has been associated with potentially dangerous cardiovascular effects in research models . The compound’s long duration of action also necessitates careful handling in experimental protocols .

Shipping Information: Worldwide Delivery

4mmcchems is committed to making our products accessible globally. We ship to all major regions, including:

• Europe: All EU member states, UK, Switzerland, Norway, and more.

• North America: USA, Canada, Mexico.

• Asia: Japan, South Korea, Singapore, China, India, and others.

• Australia & Oceania

• South America

• Middle East & Africa

Shipping Methods:

• Standard Air Mail (7-21 days, tracking available)

• Express Courier (3-7 days, fully tracked, signature required)

Customs and Duties: Customers are responsible for any customs duties or import taxes applicable in their country. We provide all necessary documentation to facilitate smooth customs clearance, subject to local regulations.

How to Order

1. Browse Our Catalog: Select 3,4-CTMP Powder and add to cart.

2. Checkout: Fill in your shipping details and choose your preferred payment method.

3. Payment: We accept cryptocurrencies and bank transfers for secure transactions.

4. Confirmation: Receive an order confirmation with tracking details upon dispatch.

Frequently Asked Questions

Q: What is 3,4-CTMP used for in research?

A: 3,4-CTMP is used as an analytical reference material for forensic and analytical applications, including method development, quality control, and transporter binding assays .

Q: Is 3,4-CTMP legal to purchase?

A: 3,4-CTMP is a regulated substance in many jurisdictions. It is the customer’s responsibility to verify the legal status of this product in their jurisdiction before placing an order.

Q: How should 3,4-CTMP be stored?

A: Store at -20°C for long-term stability. Protect from light and moisture.

Q: What if my order is seized by customs?

A: While we take every precaution to ensure successful delivery, we cannot guarantee customs clearance in all countries. Please refer to our shipping policy for more details.